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BPS BPS-Pharmacotherapy Exam Syllabus Topics:

BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A physician suspects that a patient's symptoms are related to abrupt discontinuation of a certain drug and asks the pharmacotherapy specialist about common reactions in this type of situation.
A literature search produces one case report of a discontinuation syndrome involving the drug.
What is the most appropriate action to take with regard to the current suspected adverse event?

A) Report the event to the P & T Committee.
B) Report the event to the FDA MedWatch program.
C) Write and submit a case report detailing the event.
D) Complete a manufacturer's adverse event report.

2. A 60-year-old man who is HIV-positive describes symptoms of erectile dysfunction and requests therapy. Current medications include tenofovir 300 mg orally daily, emtricitabine 200 mg orally daily, atazanavir 300 mg orally daily, and ritonavir 100 mg orally daily. In addition to counseling on preventing HIV transmission, which recommendation is appropriate?

A) Start sildenafil 25 mg/dose (maximum 25 mg in 48 hours).
B) Start sildenafil 50 mg/dose (maximum 200 mg in 48 hours) and decrease atazanavir to
150 mg orally daily.
C) Start sildenafil 25 mg/dose (maximum 25 mg in 48 hours) and decrease atazanavir to
150 mg orally daily.
D) Start sildenafil 50 mg/dose (maximum 200 mg in 48 hours).

3. A 69-year-old Woman with chronic liver disease treated with furosemide and potassium chloride for ascites and peripheral edema presents with weakness and fatigue. Her serum laboratory Values are:
* Sodium: 138 mEq/L
* Potassium: 2.6 mEq/L
* Glucose: 88 mg/dL
* BUN: 33 mg/dL
* Chloride: 101 mEq/L
* HCO3- 26 mEq/L
* Creatinine: 1.1 mg/dL
Attempts to increase her serum potassium over the next 48 hours include intravenous replacement (240 mEq over this period), without success. The current serum potassium concentration is 2.8 mEq/L. Which of the following is the most appropriate test to obtain for this patient?

A) Urinary potassium
B) Serum magnesium
C) Urinary sodium
D) Serum antidiuretic hormone

4. A population study of gentamicin pharmacokinetics in 425 neonates reported the following correlation by least-squares linear regression between gestational age and gentamicin clearance:
r2 = 0.35, p = 0.0001. Which of the following is the most appropriate interpretation of these data?

A) A correlation coefficient of less than 0.8 essentially means no significant relationship exists between gestational age and gentamicin clearance in neonates.
B) A significant correlation exists between gestational age of newborns and gentamicin clearance, but gestational age accounts for only 35% of the variability in clearance.
C) A significant correlation exists between gestational age and gentamicin clearance, with gestational age accounting for 65% of the variability in gentamicin clearance.
D) A significant correlation exists between gestational age and gentamicin clearance, with gestational age accounting for 59% of the variability of gentamicin clearance.

5. A shortage of parenteral acyclovir was just announced; a hospital has 25 vials on hand and uses
20 vials in a typical month. The wholesaler has 250 vials on hand but will not receive any more supply for 4 months. What is the hospital's most appropriate response to the shortage?

A) Develop guidelines for use of the remaining supply.
B) Order 250 vials in case the shortage is longer than expected.
C) Obtain stock from a neighboring hospital when supplies run out.
D) Issue daily updates to prescribers on inventory levels.

Solutions: