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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A pharmacotherapy specialist is interpreting a published paper describing a randomized controlled, double-bling study that was conducted to evaluate the effects of antihistamines on the failure rate of treatment of otitis media in children. In the study, 250 children received antihistamines and 264 did not. All children received appropriate antibiotic therapy. Treatment failures occurred in four (1.6%) of the children who received antihistamines and in 13 (4.9%) of those who did not. The difference is statistically significant (p<0.05, chi-square). Which of the following statements about these result is appropriate?

A) Knowledge of the rate and severity of adverse event in the study is needed to allow a therapeutic decision.
B) Chi-square is not the appropriate statistical test.
C) Antihistamines should be administered to all children with otitis media who meet study entry criteria.
D) The sample size is inadequate to allow clinical conclusions.

2. A 48-year-old African American woman presents with BP = 142/96 mm Hg. Serum chemistry values are all within normal ranges. Lifestyle modification was initiated 6 months ago when BP was 146/94 mm Hg. The pharmacotherapy specialist should recommend which of the following?

A) Continued lifestyle modification
B) Losartan 25 mg daily
C) Atenolol 25 mg daily
D) Hydrochlorothiazide 12.5 mg daily

3. To correct the development of metabolic acidosis in patients receiving standard TPN solutions, which of the following is the best therapeutic intervention?

A) Hyperventilate the patient to produce hypocapnia.
B) Decrease the chloride and increase the acetate.
C) Decrease the potassium and increase the calcium.
D) Decrease the phosphate and add bicarbonate.

4. A nurse administering an injectable narcotic is stuck with the needle. Which of the following is the most important information about the nurse's immune status to determine appropriate bloodborne pathogen/hepatitis B procedures?

A) Date of last dose of hepatitis B immune globulin
B) Current hepatitis B surface antigen (HBsAg) status
C) Dates of last hepatitis B vaccination
D) Current hepatitis B surface antibody (anti-HBs) status

5. A 47-year-old patient with cirrhosis, ascites, and acute renal failure presents to the emergency department. A peritoneal tap reveals spontaneous bacterial peritonitis (neutrophils = 789 in the ascitic fluid). Medical history includes ethanol abuse and positivity for HCV antibody. What is the most appropriate drug therapy for this patient?

A) Piperacillin/tazobactam with dextran 40
B) Levofloxacin With dextran 40
C) Gentamicin With albumin
D) Cefotaxime with albumin

Solutions: